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Multiple Tracer Assessment of Brain Edema

Barry A. Siegel, MD; Richard Meidinger, MD; A. John Elliott, MD; Rebecca Studer, MS; Charles Curtis; Janet Morgan; E. James Potchen, MD

Arch Neurol. 1972;26(1):73-77.

Abstract
Cerebral microembolism with carbon microspheres was studied by simultaneous radioactive tracer determination of the red blood cell, albumin, iodoantipyrine, and pertechnetate spaces in the rat brain. Brain edema was evident begining at four hours after embolization and was associated with decreased cerebral blood volume. Early edema was not accompanied by abnormal capillary permeability to macromolecules; however, the albumin space was increased at later times. Increases in the whole brain and the more heavily embolized right hemisphere pertechnetate spaces developed prior to similar changes in the albumin space. The iodoantipyrine space did not reliably reflect total brain water possibly due to rapid hepatic deiodination of this molecule. Our results suggest that multiple radioactive isotope label space estimation can serve as a sensitive tool for evaluation of pathophysiologic changes in ischemic brain injury.

Author Affiliations
St. Louis

From the Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis.

Footnotes
Accepted for publication July 21, 1971.

Read in part before the Association of University Radiologists meeting, Durham, NC, May 13, 1971, and in part before the 18th annual Society of Nuclear Medicine meeting, Los Angeles, June 28, 1971.

Reprint requests to Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, St. Louis 63110 (Dr. Siegel).

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