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Cerebral Catecholamines After Levodopa Therapy
Melvin Greer, MD;
George H. Collins, MD;
Aaron H. Anton, PhD
Arch Neurol. 1971;25(5):461-467.
Abstract
Dopamine levels in the striatum, pallidum, and substantia nigra of two patients with Parkinson's disease to whom levodopa had been administered for one year were below that found in control patients; however, the levels were greater than those reported in untreated patients with Parkinson's disease. Moreover, the presence of dihydroxyphenylalanine in the two brains confirmed the drug's cerebral penetration, with the highest concentrations being in the striatum, pallidum, substantia nigra, and hypothalamus. The significant pathological abnormality in one patient (striatonigral degeneration) in contrast with the other could not be correlated with a difference in the clinical course nor the biochemical findings.
Author Affiliations
Gainesville, Fla; Cleveland
From the sections of neurology (Dr. Greer) and neuropathology (Dr. Collins), University of Florida College of Medicine, and the VA Hospital Gainesville, Fla, and the Department of Anesthesia, Case Western Reserve School of Medicine, Cleveland (Dr. Anton).
Footnotes
Accepted for publication April 14, 1971.
Reprint requests to Section of Neurology, University of Florida College of Medicine, Gainesville, Fla 32601 (Dr. Greer).
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ABSTRACT
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