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An Easy, Rapid, Sensitive, Reliable, and Valid Method for the Simultaneous Determination of Immunoglobulin-G and Albumin

Wallace W. Tourtellotte, MD, PhD; Bruno Tavolato, MD; Julius A. Parker, MA; Patria Comiso, MS

Arch Neurol. 1971;25(4):345-350.

Abstract
An electroimmunodiffusion method has been standardized for the simultaneous determination of IgG and albumin in cerebrospinal fluid (CSF) and serum. It is reliable and as valid as the most precise available method, Kabat's immunochemical technique. The procedure requires only 5µl of normal CSF (unconcentrated) or normal serum diluted 200 times. The lgG/albumin quotient is as discriminative for multiple sclerosis as the accepted ratio, lgG/total protein. The proposed procedure to estimate the CSF lgG/albumin quotient is suitable for any clinical laboratory that processes CSF.

Author Affiliations
Ann Arbor, Mich

From the Department of Neurology, University of Michigan Medical Center, Ann Arbor, Mich.

Footnotes
Accepted for publication Feb 24, 1971.

Read before the annual meeting of the American Neurological Association, Atlantic City, NJ, June 11, 1970.

Reprint requests to Neurology Service, VA Wads-worth General Hospital, Wilshire and Sawtelle Blvd, Los Angeles 90073 (Dr. Tourtellotte).

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