This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

An Easy, Rapid, Sensitive, Reliable, and Valid Method for the Simultaneous Determination of Immunoglobulin-G and Albumin

Wallace W. Tourtellotte, MD, PhD; Bruno Tavolato, MD; Julius A. Parker, MA; Patria Comiso, MS

Arch Neurol. 1971;25(4):345-350.

Abstract
An electroimmunodiffusion method has been standardized for the simultaneous determination of IgG and albumin in cerebrospinal fluid (CSF) and serum. It is reliable and as valid as the most precise available method, Kabat's immunochemical technique. The procedure requires only 5µl of normal CSF (unconcentrated) or normal serum diluted 200 times. The lgG/albumin quotient is as discriminative for multiple sclerosis as the accepted ratio, lgG/total protein. The proposed procedure to estimate the CSF lgG/albumin quotient is suitable for any clinical laboratory that processes CSF.

Author Affiliations
Ann Arbor, Mich

From the Department of Neurology, University of Michigan Medical Center, Ann Arbor, Mich.

Footnotes
Accepted for publication Feb 24, 1971.

Read before the annual meeting of the American Neurological Association, Atlantic City, NJ, June 11, 1970.

Reprint requests to Neurology Service, VA Wads-worth General Hospital, Wilshire and Sawtelle Blvd, Los Angeles 90073 (Dr. Tourtellotte).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A humoral response to oligodendrocyte-specific protein in MS: A potential molecular mimic
Bronstein et al.
Neurology 1999;53:154-154.
ABSTRACT | FULL TEXT  

Intra-Blood-Brain Barrier IgG Synthesis in Cerebral Cysticercosis
Miller et al.
Arch Neurol 1985;42:782-784.
ABSTRACT  

Local Immunoglobulin Synthesis in Juvenile Periodontitis: Initial Findings
Mason et al.
JDR 1984;63:1211-1213.
ABSTRACT  

Random Fecal {alpha}1-Antitrypsin Excretion in Children With Intestinal Disorders
Dinari et al.
Arch Pediatr Adolesc Med 1984;138:971-973.
ABSTRACT  

Multiple Sclerosis De Novo CNS IgG Synthesis: Effect of CNS Irradiation
Tourtellotte et al.
Arch Neurol 1980;37:620-624.
ABSTRACT