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Hans Link, MD; Ragnar Müller, MD

Arch Neurol. 1971;25(4):326-344.

Abstract
Increased relative cerebrospinal fluid (CSF) concentrations of immunoglobulin G, immunoglobulin A, and immunoglobulin M were found in 73%, 9%, and 0% of 64 multiple sclerosis (MS) patients, in 36%, 27%, and 9% of 39 patients with central nervous system (CNS) infections, and in 16%, 14%, and 6% of 81 patients with other neurological disorders, when compared with 30 controls. Oligoclonal CSF-immunoglobulin G in the form of discrete bands on agar gel electrophoresis and abnormal kappa:lambda immunoglobulin light chain ratio was found in 94% and 53% in MS, in 39% and 0% in CNS infections, and in 3% and 3% in other neurological disorders. Immunoelectrophoresis abnormalities of the CSF-immunoglobulin G precipitation line were found in all three patient groups. The corresponding serum investigations were nearly always normal. The MS-CSF abnormalities were correlated to different clinical factors.

Author Affiliations
Lund, Sweden

From the Department of Neurology, University Hospital, Lund, Sweden.

Footnotes
Accepted for publication March 10, 1971.

Read in part before the Ninth International Congress of Neurology, New York, Sept 25, 1969.

Reprint requests to Department of Neurology, University Hospital, S-220-05, Lund, Sweden (Dr. Link).

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