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Ivan MacG. Donaldson, MRACP; Eric A. Espiner, MD, MRACP

Arch Neurol. 1971;25(3):240-244.

Abstract
Chorea gravidarum occurred due to disseminated lupus erythematosus. This diagnosis should be suspected, especially in women with chorea in the second or third decade, in whom there is not clear evidence of rheumatic fever. There is frequently no other clinical evidence of lupus for several years. Although the duration of choreiform attacks is similar to that of rheumatic fever, the tendency for recurrence is probably less. There is a high incidence of clinical involvement of other parts of the nervous system at some time during the disease. Results of cerebrospinal fluid examination are most frequently normal. The typical autopsy finding is widespread involvement of the small vessels of the cerebral cortex with fibrinoid necrosis and adjacent microinfarcts, but without demonstrable lesions in the basal ganglia. There has been at least a 20% mortality at six months.

Author Affiliations
Christchurch, New Zealand

From the Medical Unit, the Princess Margaret Hospital, Christchurch, New Zealand.

Footnotes
Accepted for publication March 18, 1971.

Reprint requests to Department of Neurology, Auckland Hospital, Park Road, Auckland 3, New Zealand (Dr. Donaldson).

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