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III. The Excretion of Copper

Sean O'Reilly, MD; Paul M. Weber, MD; Mary Oswald; Leroy Shipley

Arch Neurol. 1971;25(1):28-32.

Abstract
Stool radioactive copper was decreased and urinary excretion increased after intravenous administration of cupric chloride ⁶⁷Cu in eight homozygotes of Wilson's disease; cumulative excretion for 10 to 14 days was 3.7% to 13.2% of the dose; in six heterozygotes cumulative excretion was 7.8% to 23.8% of dose. Cumulative excretion in normal subjects was 24% to 40% of the dose. Two control subjects with hepatic failure excreted 10% and 14% of the dose respectively. The excretory data agreed well with the whole-body retention measurements in all subjects. Intermittent sampling of duodenal contents during the first few days after intravenous administration of radioactive copper suggested reduced biliary excretion as the proximate cause of decreased stool radioactive copper in the wilsonian subjects.

Author Affiliations
San Francisco

From the Clinical Study Center, and the sections of nuclear medicine and clinical neurochemistry, Clinical Laboratory Service, San Francisco General Hospital, San Francisco.

Footnotes
Accepted for publication Nov 25, 1970.

Reprint requests to Department of Neurology, George Washington University Medical Center, 2150 Pennsylvania Ave NW, Washington, DC 20037 (Dr. O'Reilly).

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