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Paavo J. Riekkinen, MD; Jorma Palo, MD; Antti U. Arstila, MD; Heikki J. Savolainen; Urpo K. Rinne, MD; Erkki K. Kivalo, MD; Harry Frey, MD

Arch Neurol. 1971;24(6):545-549.

Abstract
Myelin was purified from control and multiple sclerosis (MS) white matter. Purity of samples was checked with electron microscopy and biochemical analyses, and protein composition of myelin samples was evaluated with horizontal gel electrophoresis. Results showed a typical and consistent pattern in electropherograms with major protein constituents and some minor ones. All other proteins were similar in control and MS myelin samples except the encephalitogenic (basic) protein which showed decreased values in MS myelin. The role of encephalitogenic protein in the pathogenesis of MS is discussed on the basis of these findings.

Author Affiliations
Turku, Finland

From the Department of Neurology and Membrane Pathology Research Unit, University of Turku, Turku, Finland (Drs. Riekkinen, Arstila, Rinne, and Frey), and the Department of Neurology, University of Helsinki, Helsinki (Dr. Palo, Mr. Savolainen, and Dr. Kivalo).

Footnotes
Accepted for publication Dec 31,1970.

Reprint requests to Department of Neurology, University of Turku, Turku 3, Finland (Dr. Rinne).

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ABSTRACT