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II. Microelectrode Studies

Rainer Spehlmann, MD

Arch Neurol. 1971;24(6):495-502.

Abstract
Single neurons in the chronically isolated visual cortex of cats prepared as encéphale isolé fired rarely and usually in bursts corresponding to epileptiform electroencephalogram discharges. Microelectrophoretic application of acetylcholine induced or increased the firing of 20% of the neurons tested, ie, in the same proportion as in a previous study of intact visual cortex. In some neurons, acetylcholine facilitated burst discharges; in others, it abolished them by inducing repetitive firing; but in the majority of neurons firing bursts, acetylcholine was without effect. L-glutamate often had similar effects as acetylcholine. Although atropine blocked the facilitatory effect of exogenous acetylcholine, it did not antagonize the spontaneous neuronal firing whereas -aminobutyric acid promptly suppressed it. The results indicate that the paroxysmal neuronal discharges are not due to supersensitivity to endogenous acetylcholine.

Author Affiliations
Chicago

From the Veterans Administration Research Hospital, and Department of Neurology, Northwestern University Medical School, Chicago.

Footnotes
Accepted for publication Dec 14, 1970.

Read in part before the annual meeting of the American Neurological Association, Atlantic City, NJ, June 15, 1970.

Reprint requests to Veterans Administration Research Hospital, 333 E Huron St, Chicago 60611 (Dr. Spehlmann).

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