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Cerebrospinal Fluid Immunoglobulin G in ChildhoodMeasurement by Electroimmunodiffusion
Gerhard Nellhaus, MD
Arch Neurol. 1971;24(5):441-448.
Abstract
Cerebrospinal fluid (CSF) immunoglobulin G (IgG) was measured by electroimmunodiffusion (EID) in children aged 1 to 15 years. This method specifically measures IgG and requires only minute amounts of undiluted CSF. In children with nondemyelinative neurologic disorders, mean CSF IgG quotient of protein was 4.6% compared to 7.1% in "normal" adults in the same laboratory, a highly significant difference. In 88% of "controls," CSF IgG was below 6.4%, and in 99%, 8.2% or less. In 88% of children with "demyelinative" diseases, exclusive of subacute sclerosing panencephalitis, CSF IgG was 8.3% or higher, but significantly lower than the 14% considered compatible with multiple sclerosis in adults here. It is concluded that in children, the upper limit of normal CSF IgG by EID is 8.2%, higher values suggesting demyelinating processes. Reasons for the differences between the values for children and adults are postulated.
Author Affiliations
Denver
From the Pediatric Neurology Service, Department of Pediatrics, and Division of Neurology, University of Colorado Medical Center, Denver.
Footnotes
Accepted for publication Nov 27, 1970.
Reprint requests to 4200 E Ninth Ave, Denver 80220 (Dr. Nellhaus).
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