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Acetylcholine and the Epileptiform Activity of Chronically Isolated CortexI. Macroelectrode Studies
Rainer Spehlmann, MD;
James C. Daniels, MB, BS;
Cheng Ming Chang, MA
Arch Neurol. 1971;24(5):401-408.
Abstract
Solutions of acetylcholine were applied to the chronically isolated and the contralateral occipital cortex of cats prepared as encéphale isolé. The amounts required to produce epileptiform discharges were similar on the two sides. The spontaneous paroxysmal activity in the island was not facilitated by the application of acetylcholine but it disappeared before or at the onset of acetylcholine-induced discharges. Electrical stimulation revealed neither a decrease of the threshold for epileptiform afterdischarges nor a facilitation of spontaneous discharges on the isolated side. However, the seizure discharges in the isolated area, once induced by either acetylcholine or electrical stimulation, continued for long periods of time. The results suggest that acetylcholine acts as a convulsant stimulus without a special relationship to the intrinsic epileptiform abnormality of the isolated cortex.
Author Affiliations
Chicago
From the Veterans Administration Research Hospital and Department of Neurology, Northwestern University Medical School, Chicago.
Footnotes
Accepted for publication Dec 14, 1970.
Read in part before the annual meeting of the American Neurological Association, Atlantic City, NJ, June 15, 1970.
Reprint requests to Veterans Administration Research Hospital, 333 E Huron St, Chicago 60611 (Dr. Spehlmann).
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ABSTRACT
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