 |
|
Experimental Progressive Compression Neuropathy in the RabbitHistologic and Electrophysiologic Studies
Albert Aguayo, MD;
Cherunada P. V. Nair, MD;
Robert Midgley, MD
Arch Neurol. 1971;24(4):358-364.
Abstract
Structural and functional alterations caused by chronic progressive constriction of nerve were studied after application of siliconized rubber tubes to the sciatic nerve of 3- to 5-week-old rabbits. These studies indicated that careful application of the tube caused no initial damage. Gradual compression by unyielding walls of the tube developed between the second and third month and progressed with growth of the animal. This was associated with increasing slowing of motor conduction across the constricted segment. In histologic examination the predominant change was segmental demyelination in the compressed and neighboring portions of the nerve. Outer fibers of the compressed segment were affected more significantly than those centrally located. Biomechanical and ischemic factors may be responsible for these changes. Proximal and distal segments showed no important reduction in caliber or changes in internodal distance.
Author Affiliations
Montreal
From the Department of Neurology and Neurosurgery, McGill University, Division of Neurology, Montreal General Hospital (Drs. Aguayo and Nair), and Department of Surgery, Royal Victoria Hospital (Dr. Midgley), Montreal.
Footnotes
Accepted for publication Oct 16, 1970.
Read in part before the 39th annual meeting of the Royal College of Physicians and Surgeons of Canada, Montreal, Jan 22, 1970.
Reprint requests to Division of Neurology, the Montreal General Hospital, Montreal (Dr. Aguayo).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Comparison of motor conduction techniques in the diagnosis of carpal tunnel syndrome
Chang et al.
Neurology 2002;58:1603-1607.
ABSTRACT
| FULL TEXT
|
