This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (12)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Biochemical Study of the Peripheral Nervous System

Arnulf H. Koeppen, MD; Harry Messmore, MD; William E. Stehbens, MD, PhD

Arch Neurol. 1971;24(4):340-352.

Abstract
Peripheral nerve tissue of a patient with an electron microscopically verified interstitial hypertrophic neuropathy contained excessive amounts of water and protein but less lipid than comparable control tissue. In the tissue hydrolyzate, hydroxyproline was increased fourfold, hexosamines, twofold. The reduction of lipid was associated with higher than normal levels of cholesteryl esters. The fatty acid profile of the triglycerides, cholesteryl esters, and phospholipids showed abnormally high concentrations of stearic acid and increased stearic acid-oleic acid ratios. The lipids of myelin isolated from the diseased peripheral nerve had most of the characteristics of human peripheral myelin (lower cholesterol and galactolipid than central nervous system myelin) but differed by a higher concentration of choline phosphoglycerides.

Author Affiliations
Albany, NY

From the Research Service (Neurology and Pathology), Veterans Administration Hospital, the departments of neurology and pathology, Albany Medical College of Union University, Albany, NY (Drs. Koeppen and Stehbens), and the VA Hospital, Hines, Ill (Dr. Messmore).

Footnotes
Accepted for publication Nov 6, 1970.

Read in part before the Sixth International Congress of Neuropathology, Paris, Sept 2, 1970.

Reprint requests to Research Service (Neurology) VA Hospital, Albany, NY 12208 (Dr. Koeppen).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Lipid Analysis in Nerve Biopsy Specimens of Hypertrophic Neuropathy
Turpin et al.
Arch Neurol 1981;38:436-438.
ABSTRACT  

Sensory Neuropathy With Onion-Bulb Formation: Report of a Case With Onset in Infancy
Koto et al.
Arch Pediatr Adolesc Med 1978;132:379-381.
ABSTRACT  

A Case of Congenital Hypomyelination Neuropathy: Clinical, Morphological, and Chemical Studies
Kennedy et al.
Arch Neurol 1977;34:337-345.
ABSTRACT  

Onion Bulb Neuropathies
Pleasure and Towfighi
Arch Neurol 1972;26:289-301.
ABSTRACT