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Electromyographic Studies of Skeletal Muscle of Rat Given Cortisone
Venkatray G. Prabhu, PhD;
Y. Thomas Oester, MD, PhD
Arch Neurol. 1971;24(3):253-258.
Abstract
Progressive muscular weakness and wasting was induced in rats by prolonged administration of cortisone. Electromyographic data at various intervals revealed no evidence of established or impending neuropathy. There were no fibrillation potentials in the skeletal muscle even after eight weeks of intensive cortisone treatment. The spontaneous or evoked EMG patterns were essentially similar to those in nontreated control rats, the only difference being a somewhat decreased total electrical output (voltage and frequency of firing) of muscle from the cortisone-treated rat. Impulse transmission across the neuromuscular junction of the cortisone-treated rat was essentially the same as that of the control rat, as indicated by the magnitude of isometric twitch after direct or indirect (neural) stimulation. The effects of cortisone are exerted on muscle, not nerve or neuromuscular junction.
Author Affiliations
Chicago; Hines, Ill
From the Department of Physiology and Pharmacology, Chicago College of Osteopathic Medicine, Chicago (Dr. Prabhu), and the Research Service, Veterans Administration Hospital, Hines, Ill (Dr. Oester).
Footnotes
Accepted for publication Oct 23, 1970.
Reprint requests to Chicago College of Osteopathic Medicine, 5250 S Ellis Ave, Chicago 60615 (Dr. Prabhu).
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